ABSTRACT
Objective: To determine the surgical outcome of splenectomy in children with thalassemia major
Methods: It is an observational and descriptive study conducted in Department of Paediatric Surgery in collaboration with hematology, radiology, anesthesia and paediatric intensive care department at The Children's Hospital and the Institute of Child Health, Multan during the period of September 2007 to September 2013. A total of 50 patients suffering from thalassemia major already diagnosed and under management reffered from haematology department for splenectomy were included in this study. After admission, patients were assessed on the basis of history, clinical examination, and necessary investigations before surgery and later on follow-up. Investigations carried were CBC, PT, APTT, Viral markers, ECG, X-ray Chest, abdominal ultrasonography and ECHO if necessary. Splenectomy was performed after prophylactic vaccination against post splenectomy infections. Follow up was performed for at least two years. Blood transfusion requirements and number of hospital visits per annum before and after splenectomy were calculated and results analyzed statistically using SPSS-20
Results: Fifty patients were included in this study. Out of these fifty, 43 [86%] male and 7[14%] were female with a mean age of 9 years. Average blood transfusion requirement was 250 ml/kg/year, interval of blood transfusion was two weeks and twenty five visits per year before splenectomy. After splenectomy, requirement of blood transfusion reduced to 125ml/kg/year, interval between transfusion increased to one month and hospital visits reduced up to twelve per year
Conclusion: Blood transfusion requirement and number of hospital visits per year are decreased and interval between transfusions is increased after splenectomy. Splenectomy should not be delayed when indicated. Preoperative vaccination decreases the chance of post splenectomy infection
ABSTRACT
To compare mean platelet volume in patients with psoriasis and healthy individuals. This case control study was conducted in outpatients department and indoor of department of Dermatology, DHQ Hospital, Faisalabad. The duration of study was six months. Thirty consecutive patients of psoriais, 20 to 60 years of age and thirty age and gender matched healthy individuals were selected. 2cc venous blood sample from each subject was sent to the pathology laboratory of DHQ Hospital. Mean platelet volume [MPV] was measured as a part of blood complete analysis in Medonic M series Haematology analser. MPV was found higher in the patients of psoriasis as compared to the healthy individuals. The mean value of MPV in the case group was 8.24 +/- 1.22 fl, whereas in the control group, it was 7.29 +/- 0.77 fl [p<0.05]. The study demonstrated that mean platelet volume is increased in patients with psoriasis as compared to healthy individuals. Such patients are at an increased risk of cardiovascular complications
Subject(s)
Humans , Male , Female , Platelet Activation , Blood Platelets , Arthritis, Psoriatic/blood , Cardiovascular DiseasesABSTRACT
To determine the frequency of diseases among flood affected individuals and facilities available at relief camps of Karachi Pakistan. A cross sectional study. This study was conducted at the Department of Community Medicine, Sindh Medical College, DUHS, Karachi from July 2010 to Nov. 2010. A cross sectional study was conducted and data was collected by using a structured questionnaire. A sample size of 300 flood affected individuals were drawn by using convenient sampling methods from four different flood camps located in Karachi. Out of the 300 case studied cases studied 46.0% had malaria, 90.5% of malarial patients admitted that they did not use mosquito repellents or nettings to protect themselves. About 27.3% suffered from diarrhea and 26.7% had skin infections. Adequate water supply was supplied to 66.7% of the patients. This study concluded that malaria had higher frequency at relief camps of Karachi followed by diarrhea and skin infections